Catalog classification, reference sizes, lab math links, and source-backed data. Educational use only — not medical advice.
Researched for: MOTS-c evidence and protocol review
Also known as: MOTS-c peptide
MOTS-c is a peptide encoded within the mitochondrial 12S rRNA region, acting as a metabolic stress signal that activates AMPK and downstream signaling (also reported via CK2 and Bcl-2 pathways from the nucleus), studied for improved glucose uptake, fatty-acid oxidation, insulin sensitization, and exercise-mimetic adaptation in skeletal muscle in preclinical models. Its mechanistic biology is well-characterized in cell and animal studies, but as of 2026 there are zero completed human interventional trials of MOTS-c, distinguishing it from SS-31/elamipretide, which has extensive human trial data (see that record).
Catalog descriptions reflect research context only. Not a medical claim or treatment recommendation.
Data source: Primary literature, regulator records, trial registries, and identity-specific evidence search
Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.
The repeated 5-10 mg SC schedules are community practices. Endogenous MOTS-c studies do not validate a 10 mg RUO vial for human administration.
Supplementary research context only. Not medical advice or a treatment recommendation.
Best-effort summary of forum/Reddit discussion. This is anecdotal community commentary, not a scientific source, and does not count toward this record's verification status. Do not treat it as established fact or medical guidance.
Community dosing guides list MOTS-c (5-10 mg weekly) under both metabolic-health and longevity/mitochondrial categories, describing it as 'common in biohacking stacks' but 'still experimental' -- one of the more candidly labeled compounds in these guides regarding its unproven status. Anecdotal only -- no clinical citation was located during this review.
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Community tier-list ranking of mitochondrial/metabolic and performance peptides including MOTS-c, based on user-reported experiences; crowd-sourced opinion, not clinically verified.
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Published articles on this site that mention MOTS-c or one of its catalog aliases.
The following are third-party vendor links for this compound, provided for reference only. Some may be affiliate links, and prices/coupons are entered manually and may not always reflect the vendor's current listing. No affiliation, endorsement, or product claim is implied. Verify price, coupon validity, and product specifications directly on the vendor's site before purchase.
Third-party links — not affiliated with this site. Not a recommendation for human use. Research compounds are for laboratory and educational use only.
Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.