Humanin Research Reference

Catalog classification, reference sizes, lab math links, and source-backed data. Educational use only — not medical advice.

Researched for: Humanin preclinical therapeutic evidence

Mitochondrial Research peptide Lyophilized verified

Also known as: HN peptide

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Quick Facts

Reference Sizes

5 mg, 10 mg

Calculator

Preset available

Storage

Lyophilized: store at -20 deg C. After reconstitution: refrigerate 2-8 deg C; verify beyond-use timing against source COA.

Solubility

Sequence salt and formulation dependent

Catalog Description

Humanin is a 21-amino-acid peptide encoded within the mitochondrial 16S ribosomal RNA gene region. It exhibits cytoprotective and anti-apoptotic activity, and a related engineered analog (HumaninS14G) along with the related mitochondrial-derived peptide SHLP2 have both demonstrated chaperone-like activity - directly binding misfolded, seeding-capable islet amyloid polypeptide (IAPP) species and blocking amyloid seeding (relevant to type 2 diabetes research), without binding normal IAPP monomers. Humanin has also been studied in reproductive (testis) biology contexts.

Catalog descriptions reflect research context only. Not a medical claim or treatment recommendation.

Research Profile

Half-Life

Not established in administered human pharmacokinetic studies

Onset

Cell and animal signaling effects occur over minutes to days depending on model

Administration Routes (Research)

ICV IP or IV in animal studiesLaboratory use

Reported Research Effects

Cytoprotective and anti-apoptotic activity
Chaperone-like activity blocking IAPP amyloid seeding (relevant to T2DM research)
Studied in testicular/reproductive biology research

Reported Research Side Effects

Human safety and immunogenicity are unknown
Humanin signaling may be context dependent in cancer
Analogue data cannot be assumed for native Humanin

Data source: Peer-reviewed Humanin reviews and animal-model studies

Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.

Research Protocols Reported in the Literature

No validated human administration protocol has been published [Laboratory or animal study; Not established; Not established]Source: preclinical evidence only

Research Interactions

Flagged Avoid / Caution Combinations (Research)

Unvalidated human injection
Conflation of native Humanin with the more potent S14G analogue HNG

Reflects patterns reported in research/community literature only. Not a safety guarantee, medical advice, or interaction warning for human use.

Research Notes

The five duplicate 1 mg daily SC entries were unsupported and removed. Reviews describe Humanin and HNG as preclinical therapeutic candidates and note unresolved cancer-progression and chemoresistance questions.

Supplementary research context only. Not medical advice or a treatment recommendation.

Sources

Humanin therapeutic-target review — PubMed (NIH)
https://pubmed.ncbi.nlm.nih.gov/30582721/

Humanin neuroprotection review — PubMed (NIH)
https://pubmed.ncbi.nlm.nih.gov/38132360/

HNG mouse stroke study — PubMed (NIH)
https://pubmed.ncbi.nlm.nih.gov/16960089/

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Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.